- Safety Equipment & Supplies, Gainesville
- Sales & Marketing Consultant, Gainesville
- Salted & Roasted Nuts & Seeds Manufacturers, Gainesville
- Salvage Yards, Gainesville - Auto, Motorcycle, Boat, Trucks, etc
- Sandwich Shop Restaurants, Gainesville
- Savings & Loan Associations, Gainesville
- Savings Banks, Gainesville
- Scissors & Shears, Gainesville
- Scrap & Waste Materials, Gainesville
- Screen Printing, Gainesville
- Seafood Restaurants, Gainesville
- Security & Surveillance System & Equipment, Gainesville
- Security Brokers & Dealers, Gainesville
- Security Investigative Services, Gainesville
- Security Services, Gainesville
- Senior Citizens Centers & Meals, Gainesville
- Senior Citizens Service & Health Organizations, Gainesville
- Sewer & Drain Cleaning & Repair, Gainesville - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, Gainesville
- Sheet Metal, Gainesville
- Sheet Metal Contractors, Gainesville - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Gainesville
- Sheet Metal Work - Aluminum, Tin, Stainless Steel, etc, Gainesville - Sheet Metal Products
- Shock Absorber, Gainesville
- Shock Absorbers & Struts, Gainesville
- Shoe Repair Shops, Gainesville
- Shoe Store - More, Gainesville
- Shoe Stores, Gainesville - Mens, Womens & Kids Shoes
- Shoppers News Publications, Gainesville
- Shopping & Shopping Services, Gainesville
- Siding Contractors, Gainesville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Gainesville
- Skin Care & Cosmetology Salons, Gainesville
- Skin Care Products & Treatments, Gainesville
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- Smoked Meat Restaurants, Gainesville
- Smoking Cessation Treatment Centers & Information Services, Gainesville
- Snack Foods, Gainesville
- Snacks & Desserts, Gainesville
- Social Clubs & Organizations, Gainesville
- Social Services & Welfare, Gainesville
- Societies & Foundation Associations, Gainesville
- Sod & Sodding Service, Gainesville
- Sod Farms, Gainesville
- Southern Style Restaurants, Gainesville
- Special Coatings, Gainesville - Protective Coatings
- Special Dies Tools Jigs & Fixtures Manufacturers, Gainesville
- Special Interest Schools Or Instruction, Gainesville
- Specialty Animal Services, Gainesville
- Specialty Stores, Gainesville
- Sporting Goods Stores, Gainesville
- Sports Medicine, Gainesville - Doctors, Physicians & Surgeons
- Sports Nutrition, Gainesville
- Stadiums, Arenas, Coliseums & Athletic Fields, Gainesville
- Staffing & Support Services, Gainesville
- State Government, Gainesville
- Steel & Metal Goods, Gainesville - Steel Distributors
- Stereo, Audio & Video Equipment Dealers & Stores, Gainesville
- Stitching Services, Gainesville
- Stocks & Bond Brokers, Gainesville
- Stone And Glass Products, Gainesville
- Submarine Sandwich Restaurants, Gainesville
- Substance Abuse Outpatient Clinics, Gainesville
- Surgical Hospitals, Gainesville - Surgical Centers
- Surveyor Services, Gainesville - Surveying Service
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Gainesville
- Swimming Pools Supplies, Equipment & Accessories, Gainesville
- Swimwear & Accessories Shops, Gainesville - Water Sports Equipment
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