- Dairy Products - Wholesale & Retail, Brenham
- Dance Companies, Brenham
- Data Processing Services, Brenham
- Day Spas, Brenham
- Decorating & Designing Services, Brenham
- Decorative & Stamped Concrete, Brenham
- Dehumidifying & Ventilating Equipment, Brenham - Suppliers & Wholesalers
- Delicatessen Restaurants, Brenham
- Dentists, Brenham
- Department Stores, Brenham
- Dermatologists, Brenham - Skin Doctors, Physicians & Surgeons (Dermatology)
- Developmental Disabilities, Brenham
- Developmentally Disabled Information & Services, Brenham
- Diamonds & Precious & Semi-Precious Stones, Brenham
- Diesel, Brenham - Engine Fuels, Oils & Lubricants
- Direct Mail Advertising Services, Brenham
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- Disc Jockeys, Brenham
- Discount Stores, Brenham - Clothing, Grocery, Furniture, Etc
- Divorce & Family Law Attorneys & Lawyers, Brenham
- Doctors, Physicians & Surgeons, Brenham
- Dog & Cat Foods, Brenham
- Donuts, Brenham
- Door & Gate Operating Devices, Brenham
- Door Installation & Repair, Brenham - Garage, Glass, Screen, Sliding, French, Closet, Front, Storm, Interior & Exterior Doors
- Drains, Pipes & Sewage Materials, Brenham
- Drinking Establishments, Brenham
- Driveway, Parking Lot & Blacktop Contractors, Brenham - Construction, Repair & Maintenance
- Drug Screening Services, Brenham
- Drugs & Pharmaceutical Supplies, Brenham
- Drugs, Pharmaceutical Products & Toiletries - Wholesale & Manufacturers, Brenham
- Dry Cleaning & Laundry, Brenham - Dry Cleaners
- Durable & Non Durable Goods & Products, Brenham
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