- Dairy Farms, Winnsboro
- Day Spas, Winnsboro
- Delicatessen Restaurants, Winnsboro
- Dentists, Winnsboro
- Dermatologists, Winnsboro - Skin Doctors, Physicians & Surgeons (Dermatology)
- Dieticians & Diet Counseling, Winnsboro
- Diner Restaurants, Winnsboro
- Discount Stores, Winnsboro - Clothing, Grocery, Furniture, Etc
- Doctors, Physicians & Surgeons, Winnsboro
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- Doors & Door Frames, Winnsboro - Exterior, Interior, French, Front Entry, Patio, Storm, Garage & Sliding Glass Doors
- Drilling & Boring Equipment & Supplies, Winnsboro
- Drinking Establishments, Winnsboro
- Drugs & Pharmaceutical Supplies, Winnsboro
- Dry Cleaning & Laundry, Winnsboro - Dry Cleaners
- Drywall, Insulation & Plaster Contractors, Winnsboro - Installation & Repair Services
- Durable & Non Durable Goods & Products, Winnsboro
- Durable Goods & Products, Winnsboro
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