- Sand & Gravel Hauling, Winnsboro
- Sand Gravel & Aggregate, Winnsboro
- Sandblasting, Winnsboro - General Contractors
- Sandwich Shop Restaurants, Winnsboro
- School Bus Transportation Service, Winnsboro
- Scrapbooks & Scrapbook Supplies, Winnsboro
- Seafood Restaurants, Winnsboro
- Secondary Schools, Winnsboro
- Security & Surveillance System & Equipment, Winnsboro
- Security Brokers & Dealers, Winnsboro
- Security Services, Winnsboro
- Septic Tank Installation & Repair, Winnsboro - Septic Systems
- Septic Tank Pumping & Cleaning, Winnsboro - Septic Systems
- Septic Tanks & Septic Systems Contractors, Winnsboro - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Winnsboro - Wholesale, Dealers & Suppliers
- Shopping & Shopping Services, Winnsboro
- Signs, Winnsboro
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- Sleep Disorders Treatment & Information Centers, Winnsboro
- Social Services & Welfare, Winnsboro
- Societies & Foundation Associations, Winnsboro
- Special Interest Schools Or Instruction, Winnsboro
- Speciality Food Stores, Winnsboro
- Specialty Animal Services, Winnsboro
- Specialty Stores, Winnsboro
- Sporting Goods Stores, Winnsboro
- Sports Bars & Lounges, Winnsboro
- State Government, Winnsboro
- Steak House Restaurants, Winnsboro
- Stocks & Bond Brokers, Winnsboro
- Substance Abuse Clinics, Winnsboro - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Substance Abuse Services, Winnsboro
- Support Services, Winnsboro
- Surveyor Services, Winnsboro - Surveying Service
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